At a glance
- Botanical: Rhodiola rosea L. (root)
- Standardizations available:
- 5% Total Rosavins / 2% Salidroside
- 3% Total Rosavins / 1% Salidroside
- Form: Powder
- Item Code: 6447
- Certifications: Request current certificates for the selected grade
What RhodiolaSure™ Is
RhodiolaSure™ is extracted from the rhizomes and roots of Rhodiola rosea — a perennial plant native to Arctic and high-altitude regions of Europe and Asia. Of more than 200 species in the Rhodiola genus, R. rosea is the only one to contain rosavins (rosavin, rosin, and rosarin), which serve as the accepted analytical marker for genetically authentic R. rosea. The extract is standardized to a defined ratio of rosavins to salidroside — the two primary classes of bioactive compounds in this species.
Why Two Standardizations
The classical pharmacopoeial profile is 3% rosavins / 1% salidroside in their naturally occurring 3:1 ratio. The higher-strength 5% rosavins / 2% salidroside is offered for formulators seeking greater density of actives per dose, particularly in capsules and stick packs where dose volume is constrained. Both versions undergo identical sourcing and quality control under the GCI Sure™ program.
Mechanism
R. rosea is classified as an adaptogen — a substance that supports the body’s normal response to stressors without producing a stimulant or sedative effect at therapeutic doses. Mechanistically, R. rosea extracts modulate the hypothalamic-pituitary-adrenal (HPA) axis and influence levels of monoamine neurotransmitters including serotonin, dopamine, and norepinephrine. Rosavins and salidroside are thought to act in complementary fashion: salidroside is more directly studied in cellular and CNS models, while rosavins serve as analytical and clinical markers of authentic R. rosea material.
Why Formulators Choose RhodiolaSure™
- Two standardizations from a single supplier — simplifies sourcing across SKUs.
- Authenticated R. rosea (not adulterated with related Rhodiola species, a documented industry problem).
- Free-flowing powder suited for capsules, tablets, stick packs, and effervescent formats.
- Well-characterized adaptogen category, with growing clinical literature on stress, fatigue, and cognitive performance.
Where RhodiolaSure™ Fits
Dosage formats: capsules, tablets, stick packs, gummies, ready-to-drink shots, energy beverages, sports-nutrition powders.
Industries served: dietary supplements; functional food and beverage; sports nutrition; cosmetic (limited).
Technical Specifications
Request the current specification and lot-specific certificate of analysis for your selected grade.
| Detail | Information |
|---|---|
| Item Code | 6447 |
| Botanical | Rhodiola rosea L. (root and rhizome) |
| Available SKUs | 5% rosavins / 2% salidroside 3% rosavins / 1% salidroside |
| GMO status | Non-GMO |
For origin, test method, appearance, particle size, loss on drying, heavy metals, microbiology, pesticides, shelf life, request the current product documentation.
Ordering Information
| Detail | Information |
|---|---|
| Standard packaging | Confirm the available pack size with your quote |
| MOQ | Quoted for the selected ingredient and order quantity |
| Lead time | Request current availability and delivery timing |
| Sample availability | Yes |
Quality, Compliance & Certifications
Request current certificates and product statements for the selected grade; certification availability is subject to verification.
- Distributed under cGMP and the GCI Sure™ program.
- Request the current specification and lot-specific certificate of analysis.
Often Formulated With
- Ashwagandha, L-theanine, magnesium — for stress / sleep formulations.
- Caffeine, B-vitamins — for energy and focus formats.
- Ginseng, Cordyceps, Maca — for sports-performance stacks.
Resources
- RhodiolaSure™ specification — request through the technical documents form
- Current COA — request via form
- Dr. Koz’s Corner: adaptogens and HPA-axis topics
Bring RhodiolaSure™ Into Your Next Formulation
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease. RhodiolaSure™ is a trademark of GCI Nutrients, Inc.
Research & references
Historical references carried forward from the ingredient microsite. Research on another preparation or formulation does not establish the performance of this GCI ingredient.
- Brown R, Gerbarg P, Ramazanov Z. Rhodiola rosea: A Phytomedicinal Overview. Herbalgram. 2002;56:40-52.
- Lishmanov IuB, Trifonova ZhV, Tsibin AN, Maslova LV, Dement’eva LA. Plasma beta-endorphin and stress hormones in stress and adaptation. Biull Eksp Biol Med. 1987 Apr;103(4):422-4.
- Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302.
- Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71.
- Brown RP, Gerbarg PL (w/Graham B). The Rhodiola Revolution: Transform Your Health with the Herbal Breakthrough of the 21st Century. Emmaus, PA: Rodale; 2004.
- Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003 Dec;136(6):585-7.
- De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.
- Abidov M, Grachev S, Seifulla RD, Ziegenfuss TN. Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bull Exp Biol Med. 2004 Jul;138(1):63-4.
- Zhang L, Yu H, Sun Y, et al. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol. 2007 Jun 14;564(1-3):18-25.
- Li T, Xu G, Wu L, Sun C. Pharmacological studies on the sedative and hypnotic effect of salidroside from the Chinese medicinal plant Rhodiola sachalinensis. Phytomedicine. 2007 Sep;14(9):601-4.
- Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res. 2007 Jan;21(1):37-43.
- Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol. 2007 Jan 26.
- Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors. 2006;26(3):209-19.