At a glance
- Common name: Pyrroloquinoline quinone (PQQ)
- Form supplied: PQQ disodium salt (PQQ•Na₂)
- Standardization: ≥98% on a dry basis
- Form: Crystalline powder
- Item Code: 6214
What PQQSure™ Is
PQQ is a small, water-soluble, redox-active quinone first identified in the 1960s as a cofactor for bacterial dehydrogenases. It occurs naturally in trace amounts in fermented soy (natto), parsley, kiwi, green peppers, cocoa, and human breast milk. PQQSure™ is supplied as the disodium salt (PQQ•Na₂), the stable, water-soluble form used in commercial dietary supplements globally.
Regulatory Status
PQQ disodium salt was approved as a Novel Food ingredient in the European Union in 2018 following a positive evaluation by the European Food Safety Authority. In the United States, PQQ has been marketed as a dietary ingredient since 2008.
Mechanism
PQQ is most commonly described in the literature as a mitochondrial biogenesis-supporting compound. It activates PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1 alpha), the master regulator of mitochondrial biogenesis, and influences related transcriptional networks including SIRT1 and AMPK. PQQ is also a potent redox-active antioxidant, capable of cycling through more oxidation-reduction cycles than ascorbate and effective at neutralizing superoxide and hydroxyl radicals associated with mitochondrial dysfunction.
Why Formulators Choose PQQSure™
- Stable, water-soluble disodium salt — formulator-friendly across capsule, tablet, beverage, and gummy formats.
- Compelling story aligned with current consumer interest in mitochondrial health, longevity, and cellular energy.
- Strong synergy with CoQ10 and ubiquinol in mitochondrial-energy stacks.
- Growing peer-reviewed clinical literature in cognitive performance, exercise capacity, and inflammation markers.
Where PQQSure™ Fits
Dosage formats: capsules, softgels (in oil suspensions), tablets, gummies, ready-to-drink beverages, energy shots.
Industries served: dietary supplements; functional food and beverage; sports nutrition; healthy-aging.
Technical Specifications
Reference values below come from the specification column of a historical GCI certificate of analysis, not a current-lot result. Request the current specification and lot-specific analysis before purchase.
| Detail | Information |
|---|---|
| Item Code | 6214 |
| Common Name | Pyrroloquinoline quinone disodium (PQQ•Na₂) |
| Standardization | ≥98% on a dry basis |
| Appearance | Reddish-brown fine crystalline powder |
| Solubility | Water-soluble |
| Particle size | ≥99% through 20 mesh |
| Loss on drying | ≤12% |
| Heavy metals | Total as Pb ≤10 ppm; As ≤1.0; Cd ≤1.0; Pb ≤0.5; Hg ≤0.1 ppm |
| Microbiology | Aerobic plate count ≤1,000 cfu/g; yeast and mold ≤100 cfu/g; E. coli and Salmonella negative |
For cas number, allergens, gmo status, shelf life, request the current product documentation.
Ordering Information
| Detail | Information |
|---|---|
| Standard packaging | Confirm the available pack size with your quote |
| MOQ | Quoted for the selected ingredient and order quantity |
| Lead time | Request current availability and delivery timing |
| Sample availability | Yes |
Quality, Compliance & Certifications
Request current certificates and product statements for the selected grade; certification availability is subject to verification.
- Distributed under cGMP and the GCI Sure™ program.
- Request supplier-specific regulatory documentation for the intended market and use.
- Request the current specification and lot-specific certificate of analysis.
Often Formulated With
- CoQ10 / ubiquinol — the most common companion ingredient for PQQ.
- B-complex vitamins, alpha-lipoic acid — energy and metabolic stacks.
- LipoSerine™ — cognitive and mitochondrial brain stacks.
- Resveratrol, NMN, NR — longevity formulations.
Resources
- PQQSure™ specification — request through the technical documents form
- Current COA — request via form
- Dr. Koz’s Corner: mitochondrial health series
Bring PQQSure™ Into Your Next Formulation
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease. PQQSure™ is a trademark of GCI Nutrients, Inc.